Some news:
I looked at the Device Manager profile, and went down to mice, I have ONLY a HID mouse listed, no serial, so I cannot disable that, per one suggestion.
I tried plugging in the offending USB/Serial dongle and after the device appeared in the list of stuff, went back, and still no serial mouse.
I then went the regedit path, found the correct registry value, and changed it to a 4 as mentioned in the other article. With great expectations, rebooted without solving a thing.
I went through the Com Ports, and individually went into advanced and set each and every one to not treat or scan for it as a serial mouse, and even after cleaning those up, nothing.
Then, I noticed that I have a yellow triangle telling me that I have not installed a USB Controller driver for the computer. I did a troubleshoot, it told me the same thing, and asked if I'd like to fix it. Well, of course! After much whirring of the disk and talking with the internet, it informs me that it cannot find a driver to install. Nothing on my hard drive. The computer did not come with an install disk for windows. Nothing on Dell site except a bunch of frustrated other users looking for a driver, but no pointer to one. The Dell site doesn't provide a driver selection, either.
So for the time being I'm still searching to correct the USB Controller driver error (how the USB ports work for the mouse, the keyboard and the other com ports is beyond me, but they seem to.
And as I've said, it "used" to work just peachy.
I'm getting frustrated, so may need to take a break for a bit, too. But still hoping someone has more ideas to try.