I'm familiar with Helium as a research commodity but not much knowledge of its source. Our source was directly from the U S Bureau of Mines in Amarillo. Other sources were outrageously expensive (before 1990). I do know that it can be obtained from natural gas. The US produced natural gas has a usable amount of Helium while other countries has no usable amount of Helium in their natural gas. We had an 'Arthur Little' machine that extracted Helium but it wasn't economical to operate.
Helium is a valuable tool to use in detecting leaks in plumbing. Helium will pass through seals and even (some types of) glass. Liquid Helium is valuable as a refrigerant for research since it is the coldest liquid ~-450ºF. In transferring liquid Helium in double walled dewar plumbing, the outer surface of the pipes would get extremely cold that the air next to the pipe would condense and liquefy (frost over then drip liquid air).
When Helium escapes from containment it is lost to the atmosphere. We used Helium gas to produce liquefied air.
I don't think we'll deplete our Helium. We will consume the cheap, U S Government source, of Helium and the price will increase to the actual cost of production of Helium.