Absolutely. Here is how you do it: (make sure you have the latest version before attempting this)
Go into HW and go to "options". Find which COM port you are using. Then, completely exit HW and go into WUHU. In the "General Settings" dialog, select the option "WS23XX Direct Serial Access" and next to that, indicate which COM port you are using. Then, click "Start", and it should do it for you!
It works great for me! If you have any questions, just reply back. Also, welcome to the forum!
MODS: You might want to move this thread to the WUHU Software section.