My Wx machine runs all the Wx software(3), BlueIris with 5 or 6 cams, the Brultech software and a VM running VM95 and 3 Oly cams; all a consolidation of two (retired) Dell GX620s but with more cams.
My laptop stays at the end of the couch while at home. During NFL, I'll have a few "choice" games on CBS GameTracker going while I watch the NFL RedZone on TV, or just do the normal daily stuff - email, browsing, researching meaningless stuff, mapping/planning road trips, buying crap, etc. It also has RapidPHP and FireFTP so I can play with scripts or work on the website(s).
I've only only owned two laptops in my life and laptops are the only computers I would buy off the shelf (other than the 3 Dells from EBay). If they were easier to expand/upgrade/repair, cheaper to so and more fun to deal with than desktops, I would love to have laptops running everything just for the savings on electric.